Phd Student in Role of Small RNAs in Post-Embryonic Development of Insects

Catholic University of Leuven Kulak

Belgium

 

Your future research job is situated in the context of a novel research project of the Molecular Developmental Physiology and Signal Transduction lab (at the Biology Department of KU Leuven).This research group studies the molecular mechanisms of post-embryonic developmental processes in insects. Details about its current research topics can be viewed via the website: http://bio.kuleuven.be/df/jv.

 
Project

In metazoans, as well as in many other eukaryotes, a very large portion of the genome does not seem to code for proteins. Whereas this was initially believed to consist of ‘junk’ DNA, the advent of high-throughput sequencing methods challenged this view by the discovery of a great variety of non-coding transcript species. Currently, several classes of non-coding, regulatory RNAs are known to interfere with gene expression at different levels, as well as to be implicated in a multitude of biological processes. The discovery of this additional layer of regulatory complexity initiated a new scientific challenge, consisting of understanding the mechanisms by which non-coding transcripts exert important regulatory roles. In insects, several small RNA mediated pathways play crucial roles in antiviral immunity and development via a process that is generally designated as RNA interference (RNAi). In this project, we aim to unravel the molecular mechanisms of 'systemic RNAi', a condition in which the RNAi-signal spreads among the different cells and tissues within the insect's body, as well as to study the physiological (in vivo) significance of these spreading mechanisms. 

 

Profile

You have a MSc degree in biochemistry/biotechnology, biological sciences, bioscience engineering, or equivalent.

You have a good knowledge of animal biology, in particular entomology (both insect ecology and physiology).

You have a good knowledge of molecular biology, virology and immunology.

You are eager to learn, and have a lively interest in scientific research.

You can work very well in a team, as well as independently.

You have a positive and loyal work attitude: you are flexible and dynamic according to the requirements of the project; meticulous, involved and take your responsibilities very much to heart.

You have good communication skills, both orally and in writing (particularly in English).

You have an eye for detail, a sense of initiative and can proactively think/act.

You are efficient and stress resistant, and able to respect deadlines laid down.

You will follow the lab rules, as well as the rules of scientific integrity.

A strong interest and excellent skills in data analysis and bioinformatics are a plus.

 

Offer
Full-time (100%) fixed-term (1y) PhD fellowship, which will be prolonged on a yearly basis in case of positive evaluations [the maximal total (cumulative) duration of the PhD fellowship is 4 years].
 
Interested?
For more information please contact Prof. dr. Jozef Vanden Broeck, tel.: +32 16 32 39 78, mail: jozef.vandenbroeck@kuleuven.be.
You can apply for this job no later than August 15, 2019 via the online application tool
KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be.


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