PhD Position in Protein Engineering

Technical University of Munich Chair of Biological Imaging


PhD Student (F/M/D) in Protein Engineering: Focus on Development of Imaging Labels and Sensors

The Mission:

Genetically encoded sensors are a major tool to unravel the functioning of life on the cellular level. We seek to expand this by visualizing molecular processes on the tissue level with high resolution. The mission is to develop dedicated genetically encoded sensors for optoacoustics measurements. The candidate will focus on engineering chimeric proteins that show a small-molecule binding dependent change of photophysics. One of our main foci for readout are photo-switching proteins. Here the candidate will further explore and exploit their intricate and exciting mechanisms towards driving such proteins towards a use in applications. The workflow will span from protein-engineering and high-throughput screening over photo-physical and structural characterization to mammalian cell culture and eventual in vivo application. The work will be conducted in close collaboration with other laboratories of TUM and HMGU that are leading in the respective research areas, e.g. in vivo application or protein structure elucidation. Hence, the position is an exciting interface between protein-engineering, basic photophysical research, development of molecular tools as well as imaging.


The successful applicant must have the following:

• High motivation, curiosity, and commitment to scientific excellence
• Master Degree in Chemistry, Physics, Biochemistry or similar field
• Background in chromophores, photophysics, photochemistry
• Experience in protein engineering
• Experience in high-throughput screening
• Interest in excited state photophysics, and photoisomerization processed will be appreciated as well as understanding of (protein-) environmental effects on the photophysical properties of chromophores
• Interest in optical spectroscopy techniques
• Interest in imaging
• Team player skills and enthusiasm to work in a multi-disciplinary, collaborative environment
• Excellent command of the English language

Our offer:

We offer you the unique chance to make a difference in future healthcare. At CBI, we strongly believe in scientific excellence and innovation. This is your opportunity to be part of and to advance your career in a world-leading research institute, where bioengineering principles meet today’s challenges in biology, medicine and environmental health to develop the solutions of tomorrow. CBI provides a highly international, multi-disciplinary environment with excellent opportunities for professional growth. You will be part of a dynamic, professional and highly motivated team within a stimulating environment and gain international exposure through our partners and collaborators across Europe and the world. TUM offers a wide variety of inspiring and challenging PhD programs, which will supplement your research training with outstanding opportunities for career development, continued education and life-long learning.

Situated on the foothills of the Alps, Munich is consistently ranked as one of the most vibrant and enjoyable cities in the world, with an exceptionally quality of life. Greater Munich is also home to several world-class universities and research institutes, creating a truly inspiring intellectual atmosphere.

The successful applicant will have a 3-year contract. We offer a competitive salary and benefits depending on work experience and seniority in accordance with the public service wage agreement of the Free State of Bavaria (TV-L E13-65%). As an equal opportunity and affirmative action employer, TUM explicitly encourages applications from women as well as from all others who would bring additional diversity dimensions to the university’s research and teaching strategies. Preference will be given to disabled candidates with essentially the same qualifications.

Your application:

We are looking forward to receiving your comprehensive application including your letter of motivation, CV and academic transcripts of records preferably in English and in a single PDF file, via email to Please indicate “PhD student in protein engineering” in the subject line.

For any questions please contact:
Dr. André C. Stiel
tel.: +49 89 3187 3972
Technical University of Munich (TUM)
Chair of Biological Imaging (CBI)
Ismaningerstr. 22
81675 Munich, Germany

Hinweis zum Datenschutz:

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Kontakt: Dr. Andé Stiel

Mehr Information

In your application, please refer to