PhD Position in Microtubules

Heidelberg University

Germany

 

Microtubules are highly dynamic polymers with essential functions in chromosome segregation in mitosis and meiosis, intracellular organization, cell motility and neurogenesis. In addition, they are targets for drugs that are used in cancer therapy (Paclitaxel and Vinca alkaloids). Microtubule malfunction is associated with cancer, infertility and neurological diseases.

Using gamma-tubulin complexes, cells have developed mechanisms for the assembly of microtubules from tubulin subunits. The activity of this basic assembly machinery is modulated in time and space by accessory factors, for example microtubule polymerases and activators such as the microcephaly protein CDK5RAP2. In this project we aim to understand when and where these co-factors come in place and how their functions are changed in cancer and adapted in specific cell types, for example neurons.

The PhD student will be using a broad range of techniques such as biochemical approaches, super resolution microscopy (STED and SIM), cryo-electron microscopy, CRISPR/Cas9 technology for genomic knockins and knockouts and live cell imaging to study microtubule assembly.

Highly motivated PhD students with a background in biochemistry, cell biology or molecular biology should apply. Successful candidates will be part of an international team of PhD students and postdocs that works at the forefront of scientific research. The PhD student will be a member of the Heidelberg Biosciences International Graduate School (HBIGS) (http://www.hbigs.uni-heidelberg.de/).

 

We Offer:

The PhD position is funded for 3 years with starting date based on mutual agreement (as soon as possible).

The remuneration is based on TV-L E13, 60%.

 

Interested?

Please send applications to E. Schiebel: schiebel.elmar@zmbh.uni-heidelberg.de by no later than August 31, 2019

Mailing address: Prof Elmar Schiebel, ZMBH, University of Heidelberg, Im Neuenheimer Feld 282, D-69120 Heidelberg, Germany.

Please understand that received applications cannot be returned.

Preference will be given to disabled applicants with equal qualifications

For literature on this topic, please follow this link to our website:

http://www.zmbh.uni-heidelberg.de/schiebel/open.html


In your application, please refer to Polytechnicpositions.com

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